In contrast and although LnCaP, a prostate cancer line, proved to be particularly sensitive to metformin and in a concentration range that was within that expected clinically and correlated with a high expression of mRNA for OCT3 and low expression of MATE2 for the other cell lines, very high concentrations, up to 10mM, of metformin were required to see significant inhibition, and a strong significant correlation between inhibition of proliferation and MATE2 expression was not seen (254)
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doi:10.1385/ENDO:20:3:255 135
Nutr Neurosci
Nutritional Deficiencies The mechanism that makes GLP-1 medications effective, slowing digestion and reducing food intake, can also lead to significant nutritional gaps: Many patients consume fewer calories, making it difficult to obtain adequate nutrients Altered digestive processes may reduce the efficiency of nutrient absorption Key nutrients at risk include calcium, vitamin D, B vitamins, iron, and protein 4
The same Journal of Clinical Investigation review found no connection between semaglutide and pancreatic cancer in human studies
