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Mainly, it blocks adenosine receptors that allow endogenous adenosine to regulate a wide range of physiological processes (Ferre et al., 2018)

A dysregulated nervous system amplifies inflammation and immune reactivity

Intestinal permeability, or leaky gut, is a common trigger in autoimmunity, allowing undigested food particles and toxins to enter the bloodstream, which provokes an immune response and fuels inflammation

doi: 10.3389/fendo.2022.925206

Similarly, the rotarod test also indicated that metformin did not significantly reverse the reduced stay time induced in MIA-induced OA mice deficient in Nrf2 (Fig

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