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We propose redox activation of the AMPK may represent a new therapeutic strategy for preventing ALD

These cross-links function much like the rungs on a ladder or the steel rebar within concrete, preventing the collagen fibers from sliding past one another under physical stress

Grimaudo MA, Nicoli S, Santi P, Concheiro A, Alvarez-Lorenzo C

The use of histone deacetylase inhibitors (HDACI) modulates lipid metabolism and survival pathways in DLBCL, particularly by gaining dependency on the choline pathway and PI3K signaling activation (224), which results in a decline in the antineoplastic effects of the HDACI (224)

PMID 11918944

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