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What are the reasons behind this trend

Interestingly, most ligand interactions with TRF1 TRFH (12/19 ligands) involved the side chains of R131 or Q127, whereas only three fragments formed direct interactions with the more flexible R102 and E106 residues

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Over time, this often leads to greater productivity, stronger mental stamina, improved decision-making confidence, and a renewed sense of sharpness in both work and personal life