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The C-terminal of PLC- isoforms shows some differences, and the PLC- subfamily has a unique 450-amino acid long C-terminal extension, but the significance of this difference is unknown

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Phosphorylation of the R-domain controls dynamics and ATPase activity The R-domain interaction with NBD1, TMDs, and Lasso motif has been hypothesized to be highly dynamic and dependent on phosphorylation of the R-domain