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The temperature inside the chambers was regulated at 34.5 0.5 C to maintain the mouse rectal temperature at 36 0.5 C

Importantly, semaglutide has received regulatory approval from the US FDA, with **Ozempic** being approved in 2017, **Rybelsus** in 2019, and **Wegovy** in 2021

GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans

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