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These mechanisms exhibit significant synergy: AMPK activation not only inhibits lipogenesis and inflammation but also enhances autophagy and antioxidant responses, while lignans modulate bile acid metabolism via FXR/TGR5 agonism, and polysaccharides preferentially target SREBP-mediated lipogenic programmingunderscoring constituent-specific actions within SCFs bioactive matrix

Furthermore, if regular application or occlusion is necessary to sustain therapeutic levels, patient adherence may diminish, especially in chronic treatment contexts [348]

Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

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