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A 12-week prospective open-label study on 20 autistic children and adolescents showed YKS might be effective in treating hyperactivity, noncompliance, irritability, and agitation, though large-scale placebo-controlled trials are required

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The men were then randomized to 1 year of different maintenance strategies: placebo, exercise, liraglutide 3.0 mg, or liraglutide + exercise (this was the S-LITE trial)

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