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Lancet (2021) 398:181124

have trouble making enough thyroid hormone (hypothyroidism)

In the Phase 3 TRIUMPH-4 trial, a new safety signal called dysesthesia (abnormal skin sensations like tingling or burning) appeared in up to 20.9% of patients on the highest dose

In terms of the ingredients, Grns should be a generally safe option for healthy adults who arent pregnant, breastfeeding, or planning to become pregnant (certain ingredients may be able to cause a miscarriage).6 Additionally, some ingredients could interact poorly with certain medications or medical conditions, meaning that its best to contact your doctor before trying Grns

This is denoted by the lower right quadrant of the eDISH plot

doi: 10.5483/BMBRep.2020.53.1.279 72 LiQLiuYSunM