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Retatrutide pros Triple mechanism of action : Retatrutide targets GLP-1, GIP, and GCG, which could offer a more comprehensive approach to weight loss, blood sugar control, and metabolic health, potentially providing superior benefits over dual agonists like tirzepatide

Diabetes, Obesity, and Metabolism, 25 (4), 975-984

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A 2025 meta-analysis of three trials (878 participants) confirmed retatrutide achieved significantly greater weight reduction than placebo (mean difference approximately 14% of body weight) with no significant increase in overall adverse events [6][7]