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This study found significantly reduced peripheral blood GLP-1 levels in AD patients and model mice, with expression levels showing a significant negative correlation with PET-MR-detected brain A plaque deposition (Figure 1)

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They pretreated subjects with n-acetyl-cysteine infusion (150 mgkg -1 ) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors

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