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Rhabdomyolysis , leading to elevated creatine kinase, myoglobinuria, hyperkalemia, and possible acute kidney injury (Ndikontar et al., 2020

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Regular Weight Loss Plans: Typically include diets, exercise routines, fitness apps, or commercial programs Often use a one-size-fits-all approach, with little personalization May lack medical oversight or understanding of individual health conditions Can result in short-term success but high rates of weight regain Often fail to address hormonal imbalances or metabolic issues Medical Weight Loss: Supervised by licensed healthcare providers Begins with a comprehensive evaluation of medical history, labs, and lifestyle Customized treatment plans tailored to your body and health needs May include FDA-approved medications like GLP-1s (semaglutide, tirzepatide) Addresses root causes of weight gain (e.g., insulin resistance, hormonal shifts) Offers ongoing support, monitoring, and adjustments for long-term success Medical weight loss offers a more targeted and sustainable solution by combining medical expertise with real-world lifestyle support

Thus, there is a growing need to implement innovative strategies for assessing drug efficacy more rapidly and with greater personalization, highlighting the urgent need for advanced in vitro models, including the immune-competent, multi-tissue RA-on-chip platforms, capable of replicating the complex interplay between immune cells and joint-resident stromal components (94, 194, 195)

Although GLP-1R agonists have yielded promising results in animal models, AD transgenic mice do not fully mimic the complex pathology of human AD, and there are still some challenges in translating them into effective AD therapies

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