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Obesity is another factor associated with liver disease-specifically, the development of fatty liver and nonalcoholic steatohepatitis, a disorder similar to alcoholic hepatitis

doi: 10.1093/carcin/bgi040

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

Specifically, demethylation of the NRF2 gene promoter region can activate NRF2 expression, enhancing the binding of transcription factors and regulatory proteins to the promoter, thereby increasing the transcription and protein expression of NRF2

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