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Informative plasma markers of intestinal permeability are occludin and zonulin, which contribute respectively to the tight junction structure and to the regulation of their opening
Interrogation of the ATM data revealed specific proinflammatory transcripts, including the interferon response genes Gbp3 and Mx2 , CXCL chemokine family members ( Cxcl19 , Cxcl11 , Cxcl10 ), and C-C motif chemokine ligand 5 ( Ccl5 ), that were commonly upregulated in PAR2 mutants when compared with PAR2-WT mice (Supplemental Figure 7B)
