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In conclusion, metformin could ameliorate inflammation and oxidative stress in renal tubular cells, regulate apoptosis and autophagy, and attenuate tubulointerstitial damage through various mechanisms

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Furthermore, TQ has shown promise in leukemia by reversing DNA hypermethylation in leukemia cells, suggesting its potential role in inhibiting leukemia development (99)

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Iron overload in the body increases the levels of NTBI, which reacts with hydrogen peroxide through the Fenton reaction to generate many hydroxyl radicals (OH) and ROS