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When VSMCs undergo senescence, they adopt a pro-calcification and osteogenic phenotype (76, 77)

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Urinary glucose and creatinine were measured by colorimetric-enzymatic method using Wako Autokit glucose C2 (Wako) and L-type Wako CRE (Wako), respectively

Semaglutide is a GLP-1 receptor agonist licensed in the UK for type 2 diabetes treatment, administered as a once-weekly subcutaneous injection

Caspases assume a pivotal role in apoptosis, serving as primary executors through the cleavage of cellular proteins, thereby instigating and executing the apoptotic cascade