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YFC and BW commented on the manuscript

It repairs damage, restores elasticity, and protects against future aging

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However, antigen sampling of luminal microbes is necessary for immunological development, bacterial clearance and the production of IgA, the latter of which is important in restricting microbial adhesion to the mucosal layer and coating commensal species to limit their interaction with immune system (Johansen et al

Acknowledgments The figures presented herein were created using Biorender.com