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After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)

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Providers evaluate your health history, weight-loss goals, body composition, side effect tolerance, and lifestyle factors to help determine the most appropriate dosing strategy

FAO in dysfunctional mitochondriaa characteristic of NAFLDproduces excessive ROS and may also favor the utilization of the peroxisomes and cytochromes for FAO