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One additional note

When ROS levels in mitochondria are elevated due to electron leakage from the ETC, mitochondrial superoxide is generated, initiating a cascade of oxidative damage (90)

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They were housed under controlled laboratory conditions with a 12h/12 h light/dark cycle, at a constant temperature of 25C 1C and relative humidity of 60% 10%

These biologic agents have made incredible breakthroughs in RA treatment and their therapeutic indices are fairly high in relation to non-biologic DMARDs