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The 1-subunit is the actual transmembrane channel through which the Ca 2+ ions flow

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A small clinical trial evaluating magnesium as a potential adjunctive therapy for treating acute mania or rapid cycling BD showed a greater reduction of manic symptoms compared to controls (356), which might be due to the modulation of Ca 2+ channel activity and its participation in neurotransmitter release (357)

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Ding B, Zheng P, Jiang F, Zhao Y, Wang M, Chang M, et al

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