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Combination therapy is possible under strict medical supervision but carries cardiovascular risks because phentermine raises heart rate and blood pressure while semaglutide alters glucose and heart rate regulation

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US Office of Personnel Management

Each test lasted 13 min, with the load starting at 60 W and increasing by 15 W per minute until the participants reached their physical limits

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7.8 Avoid Extreme Restriction Very low-calorie diets ( 1520%) Significant caloric restriction Lean mass loss Persistent gastrointestinal symptoms May increase vulnerability