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Long-term results and expectations beyond year one Research following semaglutide users beyond one year shows maintained weight loss in those who continue medication, with average losses stabilizing around 15 to 17 percent of starting weight

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Published Tuesday in The New England Journal of Medicine, the Phase 3 TRANSCEND trial confirms that setmelanotide (IMCIVREE) produced a placebo-adjusted BMI reduction of nearly 20 percentage points over 52 weeks, establishing peer-reviewed evidence for the first and only FDA-approved drug targeting acquired hypothalamic obesity