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Mantaining redox homeostasis the balance between oxidants and antioxidants in cells is key for cellular physiology, and its alteration impacts on cellular processes, drives cellular responses, and is implicated in the development of several diseases (Lennicke and Cochem, 2021)

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When cellular glutathione levels drop, the accumulation of unneutralized reactive oxygen species provokes mast cells to become hyper-reactive, inappropriately releasing massive quantities of histamine into the bloodstream

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The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch