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Weight Loss: A lack of the B12 vitamin can cause the inefficient conversion of protein and fat into energy

That triple mechanism is what produced the headline-grabbing results from the Phase 2 NEJM trial, where the 12 mg dose group achieved an average 24.2% body weight reduction over 48 weeks

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Drugs like exenatide, dapagliflozin, and phentermine/topiramate are tested for their weight loss and insulin-sensitizing effects

Duration: Usually peaks 1-2 weeks then improves over subsequent 2-3 weeks

If the FDA approves GLP-1 weight loss patches in the future, patients using the patches may experience similar side effects as subcutaneous GLP-1 injections, including GI-related adverse effects