There are also data that CNI inhibitors may mediate Weibel-Palade body exocytosis
"Maternal plasma folate and vitamin B 12 are independent risk factors for neural tube defects"
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(PubMed) Reyes LH, Encinar JR, Marchante-Gayon JM, Alonso JI, Sanz-Medel A
Other bioregulators that may support lupus management include Livagen for liver support (important given the hepatotoxicity of many lupus medications), Vilon for immune regulation, Ovagen for liver and GI support, Pancragen for pancreatic function, and Bronchogen for respiratory support in cases where lupus affects the lungs