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While these findings have not been linked to serious adverse outcomes so far, they highlight the need for long-term safety studies, which are currently underway in Phase 3 trials

Some participants favourably compared GLP-1 receptor agonists with other treatment options such as bypass surgery for obesity

The STEP 4 trial, which specifically examined semaglutide withdrawal, showed that participants who stopped the medication regained 6.9% of body weight over 48 weeks, while those who continued treatment lost an additional 7.9%

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These drugs are more suitable for long-term use as studies have shown that about two-thirds of people regain the lost weight once the drug is stopped