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It is a melanocortin receptor agonist with systemic effects that include nausea, appetite suppression, and sexual side effects in 2030% of subjects at standard doses

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For example, Deng and colleagues reported that the WW domain binding protein 2 can recruit GPX4 earlier than HSC70 and therefore prevent cells from undergoing CMA-driven ferroptosis ( Beyond proteostasis Exocytosis HSP70s use a machinery similar to CMA in the formation of exosomes

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