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Patients typically start at injecting 1ml IM or SQ one to two times per week, and can titrate up or down by 0.5ml per dose depending on effectiveness and side effects

The insert included both an upstream Kozak sequence (G/A)NNATGG (where N = T or C) to promote the initiation of the translation and a downstream poly-histidine tag (10-His) to allow Ni-agarose affinity purification of the protein product

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