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The ALOX12 gene is located on human chromosome 17p13.1, a common location for monoallelic deletions in cancers
Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location
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[3] , [4] Achievement of target glucose levels, especially in the early years after T2D diagnosis, reduces the incidence and progression of microvascular complications and, in the long term (more than 10 years), is associated with reduced CV outcomes
doi:10.1530/eje.0.1500447 166
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