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& Kiemeney, L

The exact mechanism by which semaglutide might cause stomach paralysis is unknown, but it is well-recognized that GLP-1 receptors regulate stomach emptying and movement

This cascading event is exacerbated by aging with a declining proteostasis, thereby reducing the cells ability to protect its more vulnerable proteins from coaggregation, eventually resulting in the collapse of essential cellular functions

(2020) Glutamine reliance in cell metabolism

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doi: 10.1001/jama.2018.6228 86 KleeffJWhitcombDCShimosegawaTEspositoILerchMMGressTet al