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In contrast to TMX-treated rats, the protective group treated with LC showed a significant decrease in AchE (51%) and MAO (25%) activity and a significant increase in Ach, DA, and 5-HT levels (117, 84, and 37%, respectively)

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Mutations at indicated sites were introduced by site-directed mutagenesis according to the PCR Protocol for Phusion High-Fidelity DNA Polymerase (New England Biolabs GmbH, Frankfurt/Main DE)

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