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J Biol Res (Thessalonike Greece) (2021) 28(1):1

Hundreds of studies have linked small changes in weight to big benefits: Lower blood pressure : Reducing BMI by just 2.27 pointse.g., going from a BMI of 26 to a BMI of 23.7, or losing about 20 poundscan lower systolic and diastolic blood pressure by 5.79 mmHg and 3.36 mmHg, respectively

Note: Ozempic , Rybelsus , Mounjaro , Victoza , and metformin are not FDA-approved to treat obesity or for weight loss

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Some researchers attempt to salvage marginally exposed vials by immediately returning them to 28C and using them within 7 days rather than the standard 28-day window, but this creates uncertainty in downstream data