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2013 Nov;79(5):733-8 52-1

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The four key mechanisms: Brain appetite centers: Reduces food noise the constant mental preoccupation with food and cravings that many patients describe as their biggest challenge Gastric emptying: Slows how quickly food leaves the stomach, producing prolonged fullness after smaller meals Insulin response: Stimulates insulin release when blood sugar rises improving glucose management without causing low blood sugar on its own Glucagon suppression: Reduces glucagon, a hormone that signals the liver to release stored sugar unnecessarily 2

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While Ozempic and Wegovy are administered via injection once weekly, Rybelsus's daily oral intake may be more aligned with a patient's existing medication routine, potentially improving compliance