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A patient reduces sodium intake significantly in the first weeks of treatment by eating less processed food, loses some water weight, and then reintroduces higher-sodium foods, perhaps during a holiday weekend or a period of less controlled eating

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Despite these options, relapse rates remain discouragingly high, with the majority of individuals returning to problematic drinking patterns within the first year of treatment

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IgG has been demonstrated to leak into the brain interstitium of DMHC pigs via the permeable BBB

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