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Special cells, the epithelial endocrine L-cells , break down a protein called proglucagon in the intestine and produce GLP-1
M.ElK.ChenA.RohlfsR.DuBoisB.et al (2022)
While Mounjaro is only FDA-approved to treat type 2 diabetes at this time, it may gain approval for weight loss in the near future
In vitro studies typically investigate peptide activity using nanomolar to micromolar concentrations to observe cellular responses
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This dual-axis attack on energy balance simultaneously reducing input and increasing output may be responsible for the sustained slope of weight loss that was not observed with single or dual-agonist compounds in comparable timelines
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