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If GLP-1s are going to move from metabolic medicine into the worlds of pain and substance use disorders, we should talk about them the way we would talk about any powerful new class: with evidence, not mythology
Absolute insulin responses were not augmented, but they were sustained in face of the improved glycaemia which, together with the lower glucagon levels could be suggestive of an improved islet function related to the observed increase in intact GLP-1 levels (33)
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This extended half-life means your medication is still working effectively even as you approach your next scheduled dose day
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