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Then the first two amino acids including the AIB unit are also added

Additionally, glucagon has been shown to have anti-apoptotic effects on hepatocytes stimulated by Fas ligand activation and different experimental models of hepatotoxicity, and GCGR knockout results in increased hepatic susceptibility to apoptotic injury

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Lancet 2010;375:14471456

Compared to patients treated with sodium-dependent glucose transporters 2 (SGLT2) inhibitors as monotherapy, those receiving GLP-1RAs for type 2 diabetes exhibited a significantly increased risk of thyroid hyperplasia and thyroid cancer [22]