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After a 36-week lead-in period with tirzepatide treatment, participants who continued on the compound for an additional 52 weeks achieved 25.8% total weight loss

Participants receiving the highest doses (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline

Both carry thyroid tumor warnings based on animal studies

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Systemic tissue-repair dosing runs 1 mg to 2.5 mg subcutaneously, three times per week

8a), all of which reduced CAP-induced inward currents (Fig