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older adults faced a markedly higher risk than younger cohorts

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Moreover, increasing the dose of the ACTL6A HR-deleted mutant failed to reverse the reduction in GCLC mRNA expression caused by knocking down ACTL6A expression (Fig

[23] [24] However, translating these findings to human IBD requires caution, as animal models do not fully replicate the complexity of Crohn's disease

doi: 10.1249/MSS.0000000000003520

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