Choose models and readouts that align with each components preclinical literature mechanism
FDAs own safety-risk pages on bulk drug substances proposed for compounding flag concerns for several peptides popular in online circles, including issues such as limited human safety information, immunogenicity concerns, peptide-related impurities, difficult characterization, and reported serious adverse events for some molecules
As a secondary outcome of the AWARD-7 trial, which evaluated the effects of dulaglutide treatment in people with T2D and CKD, one year of treatment with dulaglutide resulted in a higher estimated glomerular filtration rate compared with insulin glargine (73)
There is no downtime with IV drips
How long does it stay active
Cleavage Products of GLP-1 Moellmann et al