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The most frequently reported adverse effects of semaglutide are gastrointestinal in nature, affecting a substantial proportion of patients during treatment initiation and dose escalation

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This novel gene-nutrient interaction with implications for blood pressure management is important in public health terms, given that the frequency of the variant MTHFR 677TT genotype is 1012 % in the UK and Ireland but it varies according to the geographical area with the highest frequency of 3244 % is reported in Mexico (Reference Wilcken, Bamforth and Li115Reference Reyes, Godfrey and Ming117)