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Other key agents in this class are dulaglutide and the novel dual GIP/GLP-1 receptor agonist, tirzepatide [16,17,18,19]

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Semaglutide GLP-1 works by mimicking the natural hormone GLP-1, which helps reduce appetite, increase feelings of fullness, and slow digestion, leading to reduced calorie intake and healthier eating habits

However, in October 2023, Pfizer discontinued its other oral GLP-1 candidate, lotiglipron, due to elevated liver enzymes observed in clinical trials

SURMOUNT-5 found that tirzepatide produced 20.2% mean weight loss versus 13.7% with semaglutide over 72 weeks in adults with obesity without diabetes a statistically significant 6.5 percentage point difference [10]

Cardiovascular, mortality, and kidney outcomes with GLP1 receptor agonists in patients with type 2 diabetes: A systematic review and metaanalysis of randomised trials