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Neutrophil extracellular traps and endothelial dysfunction in atherosclerosis and thrombosis

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Methionine serves as a precursor for S-adenosylmethionine (SAM), an important biological methyl donor, while B vitamins participate in numerous enzymatic reactions involved in amino acid metabolism, nucleic acid synthesis, and cellular energy production

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The Neh2 domain is a regulatory domain containing the DLG and ETGE binding motifs, through which NRF2 interacts with its major negative regulator, KEAP1, and is essential for the KEAP1-mediated degradation of the protein by the proteasome [128, 143,144,145]