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pmc.ncbi.nlm.nih.gov/articles/PMC7328526 [2] RSSDI Clinical Practice Recommendations, 2022

Smoking, poor diet, and chronic stress all deplete your body's natural antioxidant stores

Key triggers include a high membrane potential (m) that favors electron leak, reverse electron transport (RET) during succinate overload, ischemiareperfusion transitions with abrupt redox and calcium shifts, sustained Ca overload, substrate re-routing that alters NADH/FADH 2 supply and activation of the redox adaptor p66^Shc (Robb et al

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For example, the lifetime productivity losses among US AYAs diagnosed with cancer in 2019 were estimated at $18 billion (65)