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DIO2 mainly catalyzes the outer ring deiodination to convert T4 into T3

But in high doses, particularly via injections, it can have side effects

These pathways have contributed to widespread marketing of TB-500 as a recovery-enhancing therapy (Gonzalez-Franquesa et al

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However, because both can irritate the stomach and affect kidney function, they should be used together with caution and under the guidance of a healthcare provider