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These reactions are a continuous persistent source of potentially cytotoxic Reactive Oxygen Species(ROS)

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A gene modulator is a molecule that can interact with this system to restore a more favorable pattern of expression

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Mitophagy prevents the accumulation of dysfunctional mitochondria to ensure the quantity and quality of the mitochondrial population and maintain stable ROS levels, which lead to oxidative stress (117)

Genetic factors and medications may also play a role