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The plant is a dioecious species with small white or cream coloured (female) or pale pink (male) that grow in clusters from leaf axils

Several groups have designed monomeric dual and triple agonists based on the interactions of GLP-1 with glucagon 54,55,56 and/or GIP 57,58,59

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However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models

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