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How Does GLP-1 Work

By week 17 and beyond, most patients report substantially reduced nausea and diarrhea compared to the escalation phase

Proper dose titration (starting low and increasing gradually) significantly reduces nausea with both compounds

A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss

Clinical data supporting fat loss in humans remains limited

One of the most common questions is whether you should stop suddenly or taper gradually