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Eli Lilly Centers for Medicare & Medicaid Services

Glucagon-receptor activity is associated with increased energy expenditure and reduced liver fat, which is the mechanistic rationale for why retatrutide produced larger weight-loss figures in early trials

Caution is warranted

Semaglutide Phase 3 trials showed approximately 15 to 17% weight loss, while retatrutide Phase 2 data showed up to 24.2%

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