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The effect of long-term use of the oral contraceptives with formulations of lower doses of both estrogens and progestogens remains to be determined

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FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

c , Methylarginine and NDUFS2 western blotting of immunoprecipitated NDUFS2 in Control, Bmal1 / and Cry1/2 / MEFs (n = 2)

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